The O.Pen Vape company was founded in 2012 by Jeremy Heidl, Ralph Morgan and Christopher McElvany in Denver, Colorado. Colorado is famous of course for being the first of the U.S. states to fully legalise the recreational use of marijuana/cannabis. O.PenVape has a licensee/distribution network that covers North America (including Canada), Europe, South Africa and Jamaica. O.Pen Vape designs, manufactures and markets a range of portable vaporizers for oils, concentrates and dry herbs, as well as accessories and oil-filled cartridges, the latter manufactured employing supercritical CO2 extraction.

This is a process which is being increasingly used for industrial extraction techniques due to its low toxicity and accompanying low environmental impact. In brief, the carbon dioxide's temperature and pressure are increased to the point at which it behaves like a supercritical liquid at the supercritical points of 31.10 °C and 72.9 atmospheres (1,071 lbs/psi). In this state the CO2 expands like a gas but acts with the density of a liquid. The process's low temperature coupled with the stability of CO2 allows most compounds to be extracted with little damage or denaturing occurring. In addition, the solubility of many extracted compounds in CO2 varies with pressure thus making accurate, selective extractions possible. This has clear advantages in extracting CBD for medical usage.

O.penVAPE was, and indeed remains, a founding member of the National Cannabis Industry Association and the company's leaders are advocates for the legal and safer use of recreational marijuana. They also passionately support medical marijuana and to this end they have hired a well-qualified team of scientists to drive research and development in this area. In fact Ralph Morgan, O.PenVape's CEO, was appointed by the Denver Department of Environmental Health to serve on its Cannabis Sustainability Work Group, in December 2015, in order to define best practices and also to develop educational resources for the industry.

O.PenVape's most recent initiative was to develop a range of co-branded oil cartridges with Amsterdam's Green House Seed Co.