To some, it might seem like a scary combination, but pairing mushrooms (psilocybin) with cannabis (THC) makes for an interesting study in terms of effects. On the one hand, you have the mind-altering, trippy, hallucinogenic effects of magic mushrooms; on the other, you have the altogether more relaxative (or euphoric, depending on variety) effects of cannabis. Do these substances work together, or do they cancel each other out? Or worse – does combining these two drugs make for an altogether more difficult experience?
As more states in the US decriminalise the use of cannabis and psilocybin mushrooms for medicinal and recreational purposes, people are naturally curious about the effects of combining the two substances. While some studies suggest that both cannabis and psychedelic mushrooms offer benefits that may complement each other in specific ways - and even potentially improve well-being - it's essential to understand the potential risks and benefits before trying this combination.
Cannabis And Mushrooms: How They Work On The Body
First, let's look at the science behind cannabis and mushrooms. Cannabis contains dozens of cannabinoids, including THC and CBD, which interact with the body's endocannabinoid system to produce a range of effects, such as euphoria, relaxation, and pain relief. Conversely, mushrooms contain psilocybin and psilocin, which bind to serotonin receptors in the brain and can produce profound changes in perception, mood, and consciousness.
While cannabis and mushrooms have different mechanisms of action and different effects, some experts believe that they may work together synergistically to enhance specific effects. For example, cannabis may help to reduce anxiety or nausea that can sometimes accompany mushroom trips. In contrast, mushrooms may intensify the visual and introspective aspects of a cannabis high.
The Potential Benefits Of Mixing Cannabis And Mushrooms
While there is limited research on the effects of cannabis and mushrooms together, some users report positive experiences. Here are a few potential health benefits and wellness boosters that have been attributed to this combination:
Enhanced creativity: Cannabis is thought to stimulate creativity. When combined with mushrooms, some users report increased inspiration and creative output.
Deeper introspection: Mushrooms can lead to introspection and self-reflection, and cannabis may enhance this effect by providing a sense of relaxation and openness.


Increased sense of connection: Both cannabis and mushrooms have been shown to increase feelings of empathy and connection with others. Combining the two may enhance this effect.
Reduced anxiety and nausea:Cannabis has been shown to help reduce anxiety and nausea, which are common side effects of mushroom use.
Improved Mental Health: In recent times, studies have suggested mushrooms (or at least, psilocybin) can assist in improving mental health if dosed correctly.
However, it's important to note that some of these benefits are from anecdotal reports, and the effects of combining cannabis and mushrooms can vary significantly from person to person.
Combining cannabis and mushrooms can also increase the risk of specific side effects, such as paranoia, anxiety, and confusion. Both substances can affect brain chemistry and alter how we perceive and process information. Psychedelic drugs can change your perception of time, and a bad trip can feel like it lasts for hours, even if it’s only fifteen minutes. You’re also combining two drugs with very different effects on heart rate - chronic tetrahydrocannabinol use lowers it, while psilocybin can elevate it. In some cases, combining cannabis and mushrooms could potentially cause more serious adverse reactions, such as psychosis or seizures.
Tips On Staying Safe Combining Cannabis And Mushrooms
So, what should you keep in mind if you're thinking about mixing cannabis and mushrooms? Here are a few tips to help you stay safe and maximize the potential benefits:
Avoid high doses: Whether you're new to cannabis or mushrooms, starting with a low dose is important when experimenting with a new combination. This will help you gauge how your body reacts and prevent you from overdoing it.
Choose suitable strains: Not all cannabis strains are created equal, so keep this in mind when mixing with mushrooms. Some strains may be more relaxing or uplifting, while others may be more likely to cause anxiety or paranoia. Similarly, some mushroom strains may be more intense than others. Do your research and choose strains that complement each other well.


Consider your setting: The setting in which you use cannabis and mushrooms can have a significant impact on your experience. If you're in a comfortable and familiar environment with people you trust, you're more likely to have a positive experience than in an unfamiliar or stressful situation.
Stay hydrated: Both cannabis and mushrooms can cause dehydration, so it's essential to drink plenty of water before, during, and after your session. This can help reduce the risk of headaches, nausea, and other side effects.
Choose the correct delivery method: Both of these substances are available as edibles, but if you combine edible cannabis with mushrooms, the delayed onset can catch you unawares. Dose low and go slow.
Have a sober friend present: Even if you're an experienced cannabis and mushroom user, it's always a good idea to have a sober friend present to keep an eye on you and help you if you need it. A psychedelic experience can get intense, so a sober friend can also help keep you grounded and prevent you from getting too lost in your thoughts. Remember you’re dealing with a hallucinogen here; having someone else around could save your life if you have a bad trip.
Cannabis And Mushrooms: Safety Is Key
Of course, the best way to stay safe when mixing cannabis and mushrooms is to approach the combination with caution and respect. These substances can have powerful effects on the mind and body, and treating them with the care they deserve is important.
Many people who have tried mixing cannabis and shrooms report positive experiences, ranging from enhanced creativity and introspection to a more profound connection with nature and other people. Ultimately, whether or not you choose to mix these two substances is a personal decision that should be based on your own research and intuition - as well as the legality of both substances in your neck of the woods.
As with any substance, it's important to be informed about the potential risks and benefits before trying it out.


